intrathecal injection of amitriptyline and doxepin for spinal anesthesia in animal studies
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Intrathecal Injection of Amitriptyline and Doxepin for Spinal Anesthesia in Animal Studies
I read with a great interest the recent article by Alebouyeh et al. about intrathecal administration of amitriptyline and doxepin to induce spinal blockade and comparison of their effects with those of bupivacaine (1). Alebouyeh et al. reported that intrathecal injection of various drugs with different mechanisms is an intriguing issue in anesthesiology and pain management. Antidepressants are ...
متن کاملEvaluation of the efficacy of intrathecal injection of amitriptyline and doxepin in spinal anesthesia in comparison with bupivacaine in rats
BACKGROUND Tricyclic antidepressants (TCAs) are commonly used orally for treating chronic pain states, such as neuropathic pain. TCAs produce analgesia by various mechanisms, including sodium channels, N-methyl-d-aspartate receptors, biogenic amines, opioids, inflammatory mediators, and substance P. Studies have shown that intrathecal tricyclic administration effectively attenuates pain and the...
متن کاملevaluation of the efficacy of intrathecal injection of amitriptyline and doxepin in spinal anesthesia in comparison with bupivacaine in rats
conclusions it seems that tertiary amine drugs such as amitriptyline and doxepin had reasonable potencies of spinal blockade when compared to bupivacaine. however, amitriptyline had a more potent and long-acting spinal anesthetic effect. amitriptyline may turn out to be a clinically valuable local anesthetic. results in groups 1 and 2, a total of 3 rats died. after adjusting the concentrations,...
متن کاملsimulation and experimental studies for prediction mineral scale formation in oil field during mixing of injection and formation water
abstract: mineral scaling in oil and gas production equipment is one of the most important problem that occurs while water injection and it has been recognized to be a major operational problem. the incompatibility between injected and formation waters may result in inorganic scale precipitation in the equipment and reservoir and then reduction of oil production rate and water injection rate. ...
Accidental intrathecal injection of aminophylline in spinal anesthesia.
M EDICATION error has been an unfortunate chapter in the history of spinal anesthesia since its invention in 1899. Many catastrophic incidents have occurred from intrathecal injection of local anesthetics contaminated with other chemicals as well as the use of drugs not intended or approved for intrathecal administration. In such situations, patient outcomes depend on the nature of the contamin...
متن کاملCardiotoxicity of amitriptyline and doxepin.
The cardiotoxicity of the tricyclic antidepressants amitriptyline and doxepin were compared in an animal with acute overdose. The mean repetitive extrasystole threshold (RET) decreased 71.5% with amitriptyline and 27.5% with doxepin (mean blood levels 933 ng/ml and 1889 ng/ml). Physostigmine reversed these effects. Sodium bicarbonate had a variable effect on the lowered RET. The toxic arrhythmo...
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عنوان ژورنال:
anesthesiology and pain medicineجلد ۱، شماره ۲، صفحات ۱۱۵-۱۱۶
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